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link alternatif mitra77 Background BReast CAncer gene 1 BRCA1 and BReast CAncer gene 2 BRCA2 encode for tumor suppressor proteins which are critical regulators of the Homologous Recombination HR pathway, the most precise and important DNA damage response mechanism. Dysfunctional HR proteins cannot repair double-stranded DNA breaks in mammalian cells, a situation called HR deficiency. Since their identification