flunarizine vs betahistine kaskustoto Overall, both work well for motion sickness, but there are two main differences: Dramamine dimenhydrinate is more sedating than meclizine and is shorter-acting. It lasts around 4-6 hours per dose compared to around 12 for meclizine. Studies show that Dramamine dimenhydrinate is likely more effective for treating motion sickness than meclizine
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