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suster123 Testicular germ cell tumors GCTs are the most common solid malignancy affecting men in their 20s to 40s and typically have a favorable prognosis. 1 They can exhibit a range of histologies reminiscent of malignant germ cells seminoma, embryonic tissue embryonal carcinoma and yolk sac tumor, trophoblast choriocarcinoma, or variably differentiated nonneoplastic somatic tissues teratoma